Gotta be Amiga for the music. But lots of people prefer the Megadrive for the controls. Definitely not the FMV intro of some versions (Sega CD and PC I believe).
I haven't tried much on it yet. Putty and Rainbow Islands worked fine. I tried Pang and The Chaos Engine but they both had a guru error. Think I need to play with the ROM/memory/CPU settings. A mouse and keyboard (my mini Bluetooth keyboard has a built in track pad) is very useful for it.