I have no idea. Never played a MMO, or am I likley to. I certainly wouldn't buy a mouse with multiple thumb buttons either, no matter how many stickers it came with.

I have a keyboard with lots of keys. They work for pretty much everything I want them for in games.

 

Thumb-enriched mouses are like multiple monitors - derided by those who've not yet used them; cause of an agonising stupor when those who have find themselves without.

I looked closer. It doesn't have side tilt on the scroll wheel. :(

It's not worth £135 if I can't tilt.

programming with an onscreen keyboard? Wut? I use a Zowie FK1 because Xen told me to. It's not got loads of buttons and things. This ASUS Rog seems ridiculous and it looks ridiculous and I would not be surprised to learn that it can make noises and if so then I wager they will also be ridiculous.

It's not for me, I'd find 12 buttons a bit excessive. Don't get me wrong, I do like a few extra mouse buttons, but 12? And no side-tilt...

No, it looks gash and you can probably get better for £50. I'm still using an MX518, I even bought another one as a spare  (dance)

Twelve is like the minimum:

1. Left
2. Middle
3. Right
4. Back
5. Forward
6. DPI
7. Alt-Tab
8. Play/Pause
9. Skip Track
10. Stop after Current Track
11. Vol Up
12. Vol Down

With a tilt wheel freeing up 4/5 it's possible to make otherwise awkward multi-key shortcuts a single press - particularly ones that would otherwise require taking a hand off the mouse then putting it back afterwards to complete, and that's without even getting into macros...