Have you noticed how every time you see any article discussing MMOs and any time you try to play any MMO (irrespective of whether it includes WASD or cursor-based movement) you get a massive warning explaining how you absolutely
must use a mouse with more than two thumb buttons or it's impossible to play and you will die a thousand horrible deaths every time? ¬_¬
Perhaps you'd like to explain why the general productiveness of multiple thumb buttons and not moving the appendage half an inch to press them isn't permitted outside of the purposes of playing a game against a sufficiently large number of people.